The PathPod Podcast

IHC Talk: Small Cell Lung Carcinomas with Dr. Natasha Rekhtman

The Chromogen Siblings return to talk about small cell lung carcinomas. Drs. Mike Arnold (@MArnold_PedPath),  Andrew Bellizzi (@IHC_guy), and Sanam Loghavi (@sanamloghavi) speak with Dr. Natasha Rekhtman (@natasharekhtman) of Memorial Sloan Kettering Cancer Center. Hear about how Pathologists use IHC to identify subsets of small cell lung carcinomas, and the cycle of how molecular data informs IHC approaches and histologic classifications in Pathology.

 

Featured articles: 

SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization

https://www.jto.org/article/S1556-0864(20)30755-3/fulltext

 

POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC

https://linkinghub.elsevier.com/retrieve/pii/S1556-0864(22)00299-4

 

Featured public domain music: Alpha Hydrae, Won't see it comin'

Beyond the Scope: Genitourinary Pathology with Dr. Sean Williamson

In this segment, Beyond the Scope, we speak to pathologists about their pursuits and interests in and outside of pathology.

On this episode, host Dr. Sara Jiang (@Sara_Jiang) speaks with Dr. Sean Williamson (@Williamson_SR). Dr. Williamson is Professor of Pathology and Vice Chair of Education at the Cleveland Clinic. He is the Editor In Chief of the International Journal of Surgical Pathology, Co-Author of The Atlas of Genitourinary Pathology: A Pattern Based Approach, and author of nearly 200 peer-reviewed publications.

 

Hear their conversation about the WHO classification of genitourinary tumors, mentorship and peer-reviewed publications. Also, Dr. Williamson shares his best Disney travel tips!

 

Links to papers referenced in the episode:

Nephrogenic adenoma origin: https://pubmed.ncbi.nlm.nih.gov/12200552/
SDH-deficient RCC: https://pubmed.ncbi.nlm.nih.gov/25034258/
RCC staging survey: https://pubmed.ncbi.nlm.nih.gov/29878933/
IJSP website: https://journals.sagepub.com/home/IJS

 

Featured public domain music: US Army Blues, BugaBlue

PathPod's 5th Birthday

In this episode, we celebrate PathPod's 5th Birthday by listening back to the first ever PathPod Quiz Show from April 30, 2020.

 

Happy Birthday PathPod!

IHC Talk: AI in Pathology and IHC with Dr. Matt Cecchini

In this edition of IHC Talk, Dr. Mike Arnold (@MArnold_PedPath), Dr. Andrew Bellizzi (@IHC_guy), and Dr. Sanam Loghavi (@sanamloghavi) delve into the exciting (and sometimes intimidating!) world of Artificial Intelligence and its potential to revolutionize pathology. They're joined by special guest Dr. Matt Cecchini (@Path_Matt), a pathologist with a keen interest in AI.

What you'll discover:

• Matt's unorthodox path to Pathology
• The role of IHC in conjunction with AI.
• The need for rigor and consistency in data
• How can the practicing pathologist work with AI to improve?

Get ready for a lively discussion that covers everything from image analysis and mitigating bias to AI agents. The crew dives deep into real-world examples, current tools like ChatGPT, and even the ethical considerations as AI takes on more responsibilities in diagnostic settings. Is AI about to replace pathologists, or can it augment our abilities to deliver better patient care? Listen in and explore the possibilities with this engaging episode!

Thanks to Dr. Cecchini for using Gemini to generate this episode description, and ChatGPT to generate the cover art!

Featured public domain music: Alpha Hydrae, Won't see it comin'.

IHC Talk: Soft Tissue with Dr. David Papke

The Chromogen Siblings are back to talk about soft tissue sarcoma diagnosis and classification. Drs. Mike Arnold (@MArnold_PedPath),  Andrew Bellizzi (@IHC_guy), and Sanam Loghavi (@sanamloghavi) speak with Dr. David Papke of Harvard University. Hear about his work and thoughts on identifying new diagnostic entities in soft tissue pathology. We also hear his remembrance of the late Dr. Christopher Fletcher and the influence Dr. Fletcher had on his career and the field of soft tissue pathology.

 

Featured public domain music: Alpha Hydrae, Won't see it comin'.

PathPod Listens to the Pediatric and Developmental Pathology Podcast

In this episode, Dr. Margaret Collins of Cincinnati Children's Hospital speaks hosts Dr. Jason Wang and Dr. Michael Arnold (@MArnold_PedPath) about the Pediatric and Developmental Pathology Podcast. Hear about the journal Pediatric and Developmental Pathology, and what makes it unique. We also listen back to the first episode of the Pediatric and Developmental Pathology Podcast, featuring a conversation about the article co-authored by Dr. Collins, Eosinophilic Gastrointestinal Disorders: A New Path.

 

Featured public domain music: Main Stem by US Army Blues

PathPod Looks Back at Episode 1 of the Diversify in Path Podcast

In this episode, Dr. Michael Williams (@bluehatcomics85) and Dr. Nicole Jackson (@NicoleJacksonMD) talk with hosts Dr. Michael Arnold (@MArnold_PedPath) and Dr. Sara Jiang (@Sara_Jiang) about how the Diversify In Path podcast got started, why the podcast is important and how the series remains as relevant as ever! We also listen back to Diversify In Path Season 1 Episode 1. 

 

Featured public domain music: Main Stem by US Army Blues

Beyond the Scope: Cytopathology with Dr. Ritu Nayar

In this segment, Beyond the Scope, we speak to pathologists about their pursuits and interests in and outside of pathology.

On this episode, host Dr. Sara Jiang (@Sara_Jiang) speaks with Dr. Ritu Nayar (@NayarRitu). Dr. Nayar is the Vice Chair of Education and Faculty Development in the Department of Pathology at the Northwestern University Feinberg School of Medicine, where she is also the Director of Cytopathology and Professor of Pathology. Dr. Nayar is also the Past President of the American Society for Cytopathology, a past member of the Executive Council of the International Academy of Cytology and is currently a Trustee and President of the American Board of Pathology. She has published over 200 papers, including her work on The Bethesda System for Reporting Cervical Cytology. She has been recognized with lifetime achievement awards from College of American Pathologists, American Society of Cytopathology and the International Academy of Cytology.

 

Links to papers referenced in the episode:

1. Nayar, R. Cervical cancer prevention in the United States—where we've been and where we're going: The American Cancer Society Primary HPV Screening Initiative. Cancer Cytopathology https://doi.org/10.1002/cncy.22733
   
    
2. Implementation in action: Collaborating on the transition to primary HPV screening for cervical cancer in the United States - PubMed (nih.gov).  
   CA Cancer J Clin . 2023 Sep-Oct;73(5):458-460. doi: 10.3322/caac.21786. Epub 2023 Jun 22.
    
3. The time has come to implement primary human papillomavirus screening for cervical cancer in the United States - Franco - 2023 - Cancer - Wiley Online Library.
   https://doi.org/10.1002/cncr.34899
    
4. Nayar, R. Precision Prevention: The 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. J. Mol. Pathol. 2021, 2, 274-280. https://doi.org/10.3390/jmp2030023

Featured public domain music: US Army Blues, BugaBlue

Around The Scope: Pediatric Pathology Fellowship

In this series, PathPod gathers pathologists Around The Scope to discuss their work in depth.  In this episode, Dr. Vidyadhari Karne, a pathology resident at the University of Southern California, speaks with recent pediatric pathology fellows Dr. Lauren Kroll-Wheeler of Seattle Children's Hospital and Dr. Catherine Gestrich of Children's Hospital of Pittsburgh. What is different about fellowship compared with residency? What is it like to transition to practice as an attending?

 

Featured public domain music: Main Stem by US Army Blues

Around The Scope: Pathology in a Post-Roe World

In this series, PathPod gathers pathologists Around The Scope to discuss their work in depth.  In this episode, we hear from the authors of a Letter to the Editor: Pathology and Abortion Rights Advocacy: Considerations in a Post-Roe World, published in the American Journal of Clinical Pathology (@ajcpjournal). Dr. Mike Arnold (@MArnold_PedPath) speaks with authors Dr. Jeremy Jacobs (@jwjacobs12), Dr. Nicole Jackson (@NicoleJacksonMD), Dr. Anne Mills (@AnneMillsMD), Dr. Elisheva Shanes (@ElishevaShanes), and Dr. Garrett Booth (@DrGSBooth1) about how the end of Roe v. Wade has impacted patient care pathologists provide, from perinatal pathology, cancer diagnosis and treatment, transfusion medicine, to forensic and autopsy pathology.

 

Featured public domain music: Main Stem by US Army Blues