The PathPod Podcast

Around the Scope: Gaps and opportunities in pathology undergraduate medical education

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth. Today, we hear about how trainees in Osteopathic Medical Schools gain exposure to the field of Pathology. Our hosts, Dr. Mike Arnold (@MArnold_PedPath) and Dr. Sara Jiang (@Sara_Jiang) talk with Dr. Meredith Herman (X: @MeredithKHerman TikTok: @meredithkherman), a third year Pathology Resident at the University of Michigan; Dr. Paul Kowalski, Pathologist and Educator at Michigan State University; Dr. Adam Berry (@Aberry_Med) a first year Pathology Resident at the University of Michigan; and Dr. Peace Preston a third year Pathology Resident at the University of Pittsburgh.

What variability exists in how Osteopathic Medical Schools gain exposure to the field of Pathology? Hear our guests learned writing their article, A cross-sectional analysis of pathology exposure across COCA-accredited osteopathic medical schools: Gaps and opportunities in pathology undergraduate medical education, and find out how Pathologists can help more Osteopathic Medical Students gain experience in Pathology.

 

Featured article:

A cross-sectional analysis of pathology exposure across COCA-accredited osteopathic medical schools: Gaps and opportunities in pathology undergraduate medical education. https://www.researchgate.net/publication/392789084_A_cross-sectional_analysis_of_pathology_exposure_across_COCA-accredited_osteopathic_medical_schools_Gaps_and_opportunities_in_pathology_undergraduate_medical_education

 

Public domain music: Main Stem by US Army Blues

IHC Talk: TRBC1 in T-cell Lymphomas

The Chromogen Siblings are back to talk about TRBC1 IHC in T-cell Lymphomas! Dr. Mike Arnold (@MArnold_PedPath),  Dr. Andrew Bellizzi (@IHC_guy), and Dr. Sanam Loghavi (@sanamloghavi) speak with Dr. Pranav Patwardhan and Dr. Erika Moore of the University of Pittsburgh Medical Center about their publication in the American Journal of Surgical Pathology: The Utility of TRBC1 Immunohistochemistry in the Evaluation of T-Cell Lymphomas.

 Hear about the Hematopathology practice in different institutions, and the challenges in diagnosing T-cell lymphomas. We also hear about how Hematopathologists can use TRBC1 IHC to identify clonal populations of T-cells to support the diagnosis of T-cell lymphoma.

 

Featured article: 

The Utility of TRBC1 Immunohistochemistry in the Evaluation of T-Cell Lymphomas

https://journals.lww.com/ajsp/abstract/9900/the_utility_of_trbc1_immunohistochemistry_in_the.563.aspx

 

Featured public domain music: Alpha Hydrae, Won't see it comin'

Around The Scope: Prostate Pathology

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth.

Today, we hear about prostate pathology and how optimization of Gleason grading can improve prognostic information. Our hosts, Dr. Mike Arnold (@MArnold_PedPath) and Dr. Andrew Bellizzi (@IHC_guy) talk with Dr. Jesse McKenney, Dr. Jane Nguyen (@janenguyen44) and Dr. Sean Williamson (@Williamson_SR) of the Cleveland Clinic.

Hear about how PSA screening changed the biopsies that pathologists see, and how the art and science of re-examining Gleason grading refined prognosis for patients with prostate cancer.

 

Featured articles:

Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort: https://pubmed.ncbi.nlm.nih.gov/27635949/

Correlation of large cribriform carcinoma and "unfavorable histology" with other Gleason pattern 4 subtypes: A proof-of-principle study evaluating 485 radical prostatectomy specimens with proposal for the concept of "borderline histology": https://pubmed.ncbi.nlm.nih.gov/39644729/

Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage: https://pubmed.ncbi.nlm.nih.gov/38828674/

Classification of prostatic adenocarcinoma as favourable/unfavourable histology has high interobserver agreement in prostate needle core biopsies: https://pubmed.ncbi.nlm.nih.gov/40762236/

 

Public domain music: Main Stem by US Army Blues

PathPod Listens to the People of Pathology Podcast with Dennis Strenk

In this episode, host Dr. Michael Arnold (@MArnold_PedPath) speaks with Dennis Strenk (@dstrenkpa), Pathologists' Assistant at Wisconsin Diagnostic Laboratories, about the podcast he started in 2019, the People of Pathology podcast. Hear about how he got started as a Pathologists' Assistant and what got him interested in starting the People of Pathology podcast. Hear what he enjoys about podcasting and what he's learned. We also celebrate the 200th episode of the People of Pathology Podcast by listening to a special episode he selected. Hear about what he learned making episode 38 of the podcast, and how the connection he made with his guest, Dr. Ralph Hruban, continued in person.  

 

You can read more about Dennis Strenk and the People of Pathology Podcast in his recent profile in The Pathologist magazine.

 

Featured public domain music: Main Stem by US Army Blues

Around The Scope: Social Media

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth.

Today, we hear about social media, from #PathArt to TikTok. Our hosts, Dr. Sara Jiang (@Sara_Jiang) and Dr. Mike Arnold (@MArnold_PedPath) speak with Dr. Meredith Herman (X: @MeredithKHerman TikTok: @meredithkherman) and Julia Kochanowski (TikTok: @myforensicpath) about now pathology and medical education on social media is changing. Hear about how they create for social media, from videos to #PathArt, the connections they've made on social media and how their interactions are helping change perceptions about pathology.

 

Public domain music: Main Stem by US Army Blues

IHC Talk: Small Cell Lung Carcinomas with Dr. Natasha Rekhtman

The Chromogen Siblings return to talk about small cell lung carcinomas. Drs. Mike Arnold (@MArnold_PedPath),  Andrew Bellizzi (@IHC_guy), and Sanam Loghavi (@sanamloghavi) speak with Dr. Natasha Rekhtman (@natasharekhtman) of Memorial Sloan Kettering Cancer Center. Hear about how Pathologists use IHC to identify subsets of small cell lung carcinomas, and the cycle of how molecular data informs IHC approaches and histologic classifications in Pathology.

 

Featured articles: 

SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization

https://www.jto.org/article/S1556-0864(20)30755-3/fulltext

 

POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC

https://linkinghub.elsevier.com/retrieve/pii/S1556-0864(22)00299-4

 

Featured public domain music: Alpha Hydrae, Won't see it comin'

Beyond the Scope: Genitourinary Pathology with Dr. Sean Williamson

In this segment, Beyond the Scope, we speak to pathologists about their pursuits and interests in and outside of pathology.

On this episode, host Dr. Sara Jiang (@Sara_Jiang) speaks with Dr. Sean Williamson (@Williamson_SR). Dr. Williamson is Professor of Pathology and Vice Chair of Education at the Cleveland Clinic. He is the Editor In Chief of the International Journal of Surgical Pathology, Co-Author of The Atlas of Genitourinary Pathology: A Pattern Based Approach, and author of nearly 200 peer-reviewed publications.

 

Hear their conversation about the WHO classification of genitourinary tumors, mentorship and peer-reviewed publications. Also, Dr. Williamson shares his best Disney travel tips!

 

Links to papers referenced in the episode:

Nephrogenic adenoma origin: https://pubmed.ncbi.nlm.nih.gov/12200552/
SDH-deficient RCC: https://pubmed.ncbi.nlm.nih.gov/25034258/
RCC staging survey: https://pubmed.ncbi.nlm.nih.gov/29878933/
IJSP website: https://journals.sagepub.com/home/IJS

 

Featured public domain music: US Army Blues, BugaBlue

PathPod's 5th Birthday

In this episode, we celebrate PathPod's 5th Birthday by listening back to the first ever PathPod Quiz Show from April 30, 2020.

 

Happy Birthday PathPod!

IHC Talk: AI in Pathology and IHC with Dr. Matt Cecchini

In this edition of IHC Talk, Dr. Mike Arnold (@MArnold_PedPath), Dr. Andrew Bellizzi (@IHC_guy), and Dr. Sanam Loghavi (@sanamloghavi) delve into the exciting (and sometimes intimidating!) world of Artificial Intelligence and its potential to revolutionize pathology. They're joined by special guest Dr. Matt Cecchini (@Path_Matt), a pathologist with a keen interest in AI.

What you'll discover:

• Matt's unorthodox path to Pathology
• The role of IHC in conjunction with AI.
• The need for rigor and consistency in data
• How can the practicing pathologist work with AI to improve?

Get ready for a lively discussion that covers everything from image analysis and mitigating bias to AI agents. The crew dives deep into real-world examples, current tools like ChatGPT, and even the ethical considerations as AI takes on more responsibilities in diagnostic settings. Is AI about to replace pathologists, or can it augment our abilities to deliver better patient care? Listen in and explore the possibilities with this engaging episode!

Thanks to Dr. Cecchini for using Gemini to generate this episode description, and ChatGPT to generate the cover art!

Featured public domain music: Alpha Hydrae, Won't see it comin'.

IHC Talk: Soft Tissue with Dr. David Papke

The Chromogen Siblings are back to talk about soft tissue sarcoma diagnosis and classification. Drs. Mike Arnold (@MArnold_PedPath),  Andrew Bellizzi (@IHC_guy), and Sanam Loghavi (@sanamloghavi) speak with Dr. David Papke of Harvard University. Hear about his work and thoughts on identifying new diagnostic entities in soft tissue pathology. We also hear his remembrance of the late Dr. Christopher Fletcher and the influence Dr. Fletcher had on his career and the field of soft tissue pathology.

 

Featured public domain music: Alpha Hydrae, Won't see it comin'.